Present Institution:

National Institute of Mental health and Neurosciences

Location:

Bangalore IN

Career Status:

Faculty Academia
Professor
Government Scientist Academician Scientist

Bio

I have keen interest in Parkinson’s disease (PD) research in both translational and basic science aspects since last 20 years and would like to further contribute to this field. In this quest
my team has contributed to 1) Translational research involving identification and validation of potential biomarkers for patients of PD with cognitive impairment 2) A non-neurotoxin-based animal model for PD with cognitive impairment and 3) Novel animal models to understand resilience to PD. Recently
we attempted identification of protein biomarker(s) in CSF of Parkinson’s disease
PD with cognitive impairment
normal pressure hydrocephalous patients and controls. Our current investigations are focussed on examining their pathogenic potential by intraperitoneal administration into adult C57BL/6J mice. My team also attempts to 'understand the molecular and cyto-morphological mechanisms of aging and age-related neurodegenerative disease'
We found that pathways involving Lewy body formation
endoplasmic reticular stress
apoptosis and growth factor receptors showed sub-threshold neurodegeneration in Asian-Indians. We also demonstrated the role of glia in aging and PD. In the last decade
we have established a mouse model to understand the factors of resilience to PD; viz. dopaminergic neurons
developmental and age-related neuronal death
growth factors
alpha-synuclein levels
motor behavior
striatal field potentials
glia/interneurons
organelles etc.

Interested in presenting:

Neurodegenerative disorders
Global Networking

Sample of a Science/Scholarship Abstract

1) Invited talk on Basic science works which failed / excelled in the last few years (in Parkinson's Disease) - Why did they? at “Neurodegeneration & Neurogenetics: The Future of Indian Collaboration” Chancery Pavillion
Bangalore May 6-7
2023
2) Invited talk: My Journey in Neuroscience Research: Much of Philosophy and a trickle of Science
Department of Biochemistry and Forensic Science
Gujarat University. August 22
2023. 3) Invited talk on: Biomarker validation draws insights into disease pathogenesis: Nota bene Parkinson's disease with cognitive impairment at the ISN-MLSU First Neurochemistry School on ‘Advances in Neurochemical Research Techniques & Management of Neurological Disorders’ at Department of Pharmaceutical Sciences
MSLU University
Udaipur 18 - 24 January 2024 4) Invited talk on: Exploring organellar hierarchy in Parkinson’s disease pathology at Frontier Symposium in Biology at the School of Biology
IISER Thiruvananthapuram
Kerala
India from Feb 2- 4
’24. 5) Invited talk on: Parkinson's Disease - current research in India on April 6
2024 at the Indian Institute of Bangalore
India.

What type of talks have you presented in the past?

None